Umba River on Mkomazi’s south eastern border and other water holes keep the park teeming with small and large mammals, including silver backed jackal, lion, cheetah, leopard, giraffe, buffalo, elephant and zebra, with the rare gerenuk, lesser kudu and fringe-eared oryx easily sighted. There is a sanctuary for the endangered black rhino and another one for the wild dog created within the national park to protect these rare species. The Mkomazi Rhino Sanctuary has attained international renown for rehabilitating rhino, and it offers viewing and educational opportunities for visitors. Mkomazi is a fascinating destination for bird watchers, boasting more than 450 avian species including some Eurasian migratory species.

Quite a few activities can be conducted in Mkomazi, including game drives, walking safaris, mountain hikes and bird watching. Mkomazi can be visited throughout the year, with late June to early September best for large mammal and bird watching, Mkomazi National Park would smoothly fit into the Arusha – Usambara – Tanga – Pangani – Saadani – Dar es Salaam / Zanzibar circuit, or may be visited as a single destination from Arusha or after Kilimanjaro climbing.